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Role of oxidative strees induced by hydrogen peroxid on intiation and development of atheroslerosis in mature femal rat

    Authors

    • E. R. AL- Kennany
    • E. Y. Al-Khafaf
,
10.33899/ijvs.2006.62477
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Abstract

This study was conducted to determine the possibility of 0.5% H2O2 on drinking water, for the induction of oxidative stress status in mature female rats. Moreover, this study deals with the role of this stress in initiation and development of atheromatus lesions in these animals. Oxidative stress has been investigated via tissue malondiadehyde (MDA) & glutathione (GSH) (aorta, heart and liver) as indirect lipid peroxidation index. For atherogenous follow up, light and electron microscopical techniques have been applied.
The result elucidate significant elevation in lipid profile parameters namely cholesterol, Triglycerides TG, Low density lipoprotein LDL-C, Very Low density lipoprotein VLDL-C, atherogenic index and a significant reduction in High density lipoprotein HDL-C, level in all experimental animals. Parallely, this study revealed significant rising in tissue MDA concentration, concomitant with significant depress in tissue GSH level in all studied animals.

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Iraqi Journal of Veterinary Sciences
Volume 20, Issue 1
June 2006
Page 139-151
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History
  • Received: 01 June 2006
  • Revised: 20 June 2006
  • Accepted: 25 June 2006
  • Published: 28 June 2006
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APA

R. AL- Kennany, E., & Y. Al-Khafaf, E. (2006). Role of oxidative strees induced by hydrogen peroxid on intiation and development of atheroslerosis in mature femal rat. Iraqi Journal of Veterinary Sciences, 20(1), 139-151. doi: 10.33899/ijvs.2006.62477

MLA

E. R. AL- Kennany; E. Y. Al-Khafaf. "Role of oxidative strees induced by hydrogen peroxid on intiation and development of atheroslerosis in mature femal rat". Iraqi Journal of Veterinary Sciences, 20, 1, 2006, 139-151. doi: 10.33899/ijvs.2006.62477

HARVARD

R. AL- Kennany, E., Y. Al-Khafaf, E. (2006). 'Role of oxidative strees induced by hydrogen peroxid on intiation and development of atheroslerosis in mature femal rat', Iraqi Journal of Veterinary Sciences, 20(1), pp. 139-151. doi: 10.33899/ijvs.2006.62477

VANCOUVER

R. AL- Kennany, E., Y. Al-Khafaf, E. Role of oxidative strees induced by hydrogen peroxid on intiation and development of atheroslerosis in mature femal rat. Iraqi Journal of Veterinary Sciences, 2006; 20(1): 139-151. doi: 10.33899/ijvs.2006.62477

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