Capability of hydrogen peroxide to induce oxidative stress and initiation of athromatus lesions and to study effect of some antioxidants represented by estradiol, vitamin e and fresh garlic in overictomized rats

Al-Khafaf, A.Y.; R. Al-Kennany, E.

doi:10.33899/ijvs.2007.5632

Capability of hydrogen peroxide to induce oxidative stress and initiation of athromatus lesions and to study effect of some antioxidants represented by estradiol, vitamin e and fresh garlic in overictomized rats

A.Y. Al-Khafaf

E. R. Al-Kennany

Iraqi Journal of Veterinary Sciences, 2007, Volume 21, Issue 1, Pages 93-110
10.33899/ijvs.2007.5632

Abstract

This study was conducted to determine the possibility of 0.5% if H2O2 on drinking water for the induction of oxidative stress status overictomized rats, moreover, this study deal with role of the stress in initiation & development
atheromatus lesions. In these animal for improvement the oxidation status, this status deal with some antioxidant agents mainly: Vitamin E, Oestradiol Benzoate and Fresh garlic. The result remarks the similar (but not identical) effect of these agents (Vit E as superior) via its lowering effect on lipid profile as well as lipid peroxidation index, and its ameliorating effects on HDL-c, tissue GSH level. Moreover, these agents show a reduction in fatty depositions in aorta of treated rats.

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