Iraqi Journal of Veterinary Sciences

Abstract

The study investigated, for the first time, the effect of the lipopolysaccharide (LPS) secreted by Escherichia coli, as an immunomodulator, against infection with giardiasis caused by Giardia lamblia in Rattus rattus norvegicus. The pathological changes occurred in the rats treated with LPS, were followed in comparison with the control groups, along the experiments period, depending on many criteria, included the changes in total and differentiated count of leukocytes. The results showed an elevation in the total count of leukocytes, expressed by elevation in neutrophils, variation in monocytes numbers accompanied with a decrease in lymphocytes numbers in treated rats in comparisons with the control groups. Results are provided that (LPS) modulates the immune defence of rats against infection with giardiasis.