This study was conducted to investigate the role of Ginger as antihyperlipidemic agent and its histopathological effects in rats exposed to oxidative stress. Results of rats treated with hydrogen peroxide (H2O2) 1% in drinking water, showed highly significant increase in the level of low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) and atherogenic index, which are indicators for the occurrence of serum hyperlipidemia. Rats treated with H2O2 then with Ginger at 2 mg/kg in diet, revealed significant decrease in the level of LDL-C, VLDL-C and atherogenic index. Histopathological study illustrate no changes in rats treated with Ginger in heart and liver tissues, while rats treated with H2O2 then with Ginger, showed amelioration in histological picture of heart and liver tissues compared with rats treated with H2O2. In conclusion, The Ginger considered as a good antihyperlipidemic agent.