Abstract

This experiment was conducted to study the effects of sub chronic exposure of Meloxicam in male albino rats by measuring Hematological, Biochemical and Histopathological changes of Livers in (18) rats divided equally into two treatment groups, T1 which dosed with 0.2 mg/KG.BW as therapeutic dose and T2 which dosed with 0.6 mg/KG.BW as three fold dose, while the other (6) animals considered as control group dosed with distilled water by stomach tube for duration (2) months. Evaluation of complete blood picture (RBCs and WBCs counts, differential WBCs count, platelets count, PCV and Hb), clotting time and serum level of liver enzyme function, Blood urea (BU) and histopathological examination of liver was performed at the end of experiment. The results revealed significant decrease in platelets count (P≤0.01) of both treated groups and significant increase clotting time of T2 group (P≤0.01) in comparison with the T1 group and control one. The results of differential count of white blood cells registered significant decrease(P≤0.05) in neutrophils and significant increases (P≤0.01) in Monocytes and Lymphocytes of both treated groups in comparison with control group. The results of serum level of liver enzymes function revealed only significant increase (P≤0.01) in AST of both treated groups in comparison with the control one, while the histopathological study of liver showed lesions was vary between vasodilatation, vasocongestion and necrosis, karryorrhexis of hepatocytes.