Abstract

The present study was conducted on (40) white mice of approximately the same age (4-6 weeks) and body weight (23-25 gm) for the aim of observing the histopathological changes for kidneys due to prolonged treatment (6 months) with anticancer chemotherapeutic agent namely methotrexate. Forty mice were divided into 4 groups (10 mice of each group, 5 mice per sex). The first group (low or therapeutic dose group) was received 0.15 mg/kg. The second group (intermediate dose group) received 0.3 mg/ kg. The third group (toxic dose group) received 0.45 mg / kg. The fourth dose group was a control group; it received 0.2 ml buffered normal physiological saline. All these groups injected intramuscularly, once weekly dose for 6 months. The results showed that methotrexate cause damage and severe toxicity in renal convoluted tubules and glomeruli in kidneys.