Abstract

The study was intended to compare the efficacy of different anesthetics combinations for induce general anesthesia in rabbits. Eighteen adult (12-18 months) local breed rabbits of either sex weighting from (980-1800) gm were used in this study. Rabbits were divided into three equal groups (3 males - 3 females) in each group. The study include induce general anesthesia by intramuscular injection of different drugs as following: droperidol (1.25mg/kg)+fentanyl 0.025mg/kg+ketamine 25mg/kg (D+F+K) group (A). xylazine (2.5mg/kg) + fentanyl 0.025mg/kg + Ketamine 25mg/kg (D+F+K) group (B). Diazepam 1mg/kg + fentanyl 0.025mg/kg + ketamine 25mg/kg (D+FF+K) group (C). The rectal temperature, respiratory rate, heart rhythm, degree of analgesia, degree of muscle relaxation and eyes reflexes (palpebral and corneal reflexes, size of pupil, were recorded before the i.m. injection of the drugs (time zero) as a control data and after 5, 10, 15, 20, 30, 45, 60, 75 minutes of injection respectively until the rabbit response to external stimuli, the induction time, anesthesia time and recovery time were recorded. An orthopedic surgery (femur periosteum elevation) was done to estimate the efficiency of the anesthetic programs. There were no significant difference in induction time, while the anesthesia time in X+F+K group was significantly longer than in the other groups. The recovery time in D +F+K group was seen significantly longer than in the other groups. The analgesia and muscle relaxant were seen superior in X+F+K group. In conclusion mixture of (X+F+K) seem to be superior asrental general anesthestic drug in rabbits.