Abstract

This study evaluated the effects of neonatal exposure to different doses 0f estradiol benzoate (EB) coadministration with single dose of testosterone propionate (T) in day 30 of age on the sexual behavior of male rats at 120 days old. Albino male rats (5 per group) recived SC injections of 0.1 ml corn oil containing EB at a dose of 0.015, 0.15, 1.5, 15, 150 Mg. per rat on alternative days from postnatal days 2-12, with coadminstration T (100 mg / rat in day 30 of age). Control animals received corn oil only. Testosterone group received single dose of 100 mg of T at day 30 of age. All animals were allowed to develop until 120 days. Sexual behavior was measured during a 15 – min behavior test with adult albino female rats at 120 days. Male rat copulatory pattern (mounting, intromission and ejaculation) where assessed. Result show that low doses of EB (0.015, 0.15 mg) with testosterone as well as testosterone group lead to significant decrease in time interval to first copulatory, and significant increase in number of intromission and ejaculation ,while high dose of EB (1.5, 15, 150 Mg) with T cause significantly decrease in sexual behavioral (especially in intromission and ejaculation).