Abstract

The present study has been designed to determine the hematological and biochemical changes of lead acetate toxicity as well as the interaction of vitamin E in relieving these changes. Forty mature male rats have the same age and weight, were randomly divided into four equal groups: control and three treated groups drenched (for 60 days) drinking water (C), lead acetate solution (400 ppm) (T1), vitamin E (30 mg/kg B.W) (T3) and lead acetate solution (400 ppm) plus vitamin E (30 mg/kg B.W) (T4). The results revealed significant decrease of RBC count, Hb concentration and PCV, and significant increase of total WBC count and neutrophil count, as well as significant decrease of lymphocytes and monocytes, while eosinophil increment didn't reach the significant level. Serum biochemical results showed significant decrease of serum total protein and albumin, significant increase of globulin concentration, ALT, cholesterol, while AST and ALP showed slight increase didn't reach the significant levels. On other hand, the results showed that drenching vitamin E had an efficient effect in improving the toxic effects of lead acetate and relieving its toxicological changes by modulating the different hematological and biochemical parameters. It can be concluded that exposure to lead compounds leads to many distinct toxic effects on different organs and systems of the body which may results in many hematological and biochemical disturbances. This study, also, proved that vitamin E have an important efficient role in improving the toxicological changes resulted from lead acetate poisoning.