Abstract

This study concerned with the efficacy of six selected antibiotics to evaluate their effect as mono- and combined experimental therapy of toxoplasmosis induced in mice. These antibiotics are: clindamycin, clarithromycin, ciprofloxacin, spiramycin and roxythromycin a well as the compound methoprim (sulphamethaxazol SMZ-trimethoprim TMP). These antibiotics showed obvious inhibitory effect on the viability of Toxoplasma gondi in infected mice, as these antibiotics prolonged the survival rate of treated mice and the mortality rate was decreased compared with control non treated group of mice died during short period of time due to acute toxoplasmosis. High cure rate 100% was occurred in mice with acute induced toxoplasmosis when treated with 300 mg/ kg/day clindamycin for one and two weeks, while the dose of 500 mg/kg/day ciropofloxacine resulted in 88.88% cure rate, and a cure rate 64% resulted in mice treated with 500 mg/kg/day spiramicin. No cure was obtained, but prolonged survival rate only in chronically infected mice treated with 250 mg/kg/day clarithromycin.