Abstract

The aim of the present study was to assessment of developmental toxic effects in suckling pups of rats exposed to enrofloxacin through the milk. Suckling offspring of rats from dams treated with enrofloxacin (30, 60, 120 mg/kg, i.m.) for 5 consecutive days (first nursing period) demonstrated in dose dependently retardation in somatic growth which appearred as a significantly decreased index of development accompanied by a significantly delayed in maturation landmark of development (fur development, tooth eruption, eye opening) in comparison with the control value. In addition, significantly increased in the plasma Alanine amino transferase activity as well as the response time to surface righting reflex on postnatal day (PND3, 4 and 5) was significantly delayed in pups from dams treated with enrofloxacin (120 mg/kg) in comparison with the control group. In conclusion, the results suggest that enrofloxacin induced developmental toxic effects in suckling pups of rats exposed to its through the milk.