Abstract
Study was conducted on 20 local buffalo breed (Bubalus bubalis) in mosul area naturally infected with mange depending on Clinical signs that appeared on animal like itching, restlessness, loss of hair, appearance of crusts, thickened skin and some time redden and oozing of blood and serum from infected area, with emaciation and laboratory examination of skin scraping taken from infected animal revealed that all of buffaloes were infected with sarcoptic mange. Animals were divided into two groups of equal number (10 for each). First group were treated by ivermectin 0.02 mg\kg sub cut single dose, while second group animals were treated by cypermethrine as washing in dilution at 1:800 single dose. Animals were clinically and skin scraping examined before treatment, 7, 14, 21 and 28 days after treatment, mites viability and mites number and there ova were detected in 10 mg of skin scraping. Lesions distributed mainly on neek, head, sacrum, front and hind legs and around the tail, and some time involve entire the body. Animals of the first group treated by ivermectin responded better than those of second group treated by cypermethrine.