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Synthesis of new 1,2 dithiol 3-thione fluoroquinolone esters possessing anticancer activity in-vitro

    B.B. Saeed M.A. Al-Iraqi F.T. Abachi

Iraqi Journal of Veterinary Sciences, 2012, Volume 26, Issue Suppl. IV, Pages 115-121
10.33899/ijvs.2012.168748

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Abstract

Three 1,2 dithiole 3-thion fluoroquinolone esters (2-4) were prepared via condensation of (p-hydroxyl phenyl) -1,2dithiole- 3-thione with fluoroquinolones (Ciprofloxacin, Gatefloxacin and Moxifloxacin). The biological activity of these compounds was assayed against 60 types of cancer cells in vitro. The compound 2 (NSC=760553) showed anticancer activity against renal cell, while the comound 4 (NSC=760555) show activity against three types of cancer cell. The expected mechanism of their activity is that 1,2dithiole 3-thione derivatives may give H2S as new gas transmitter which play an important role in the biological systems.
Keywords:
    Fluoroquinolone Anticancer Ciprofloxacin Gatefloxacin Moxifloxacin
Main Subjects:
  • Veterinary Pharmacology and Toxicology
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(2012). Synthesis of new 1,2 dithiol 3-thione fluoroquinolone esters possessing anticancer activity in-vitro. Iraqi Journal of Veterinary Sciences, 26(Suppl. IV), 115-121. doi: 10.33899/ijvs.2012.168748
B.B. Saeed; M.A. Al-Iraqi; F.T. Abachi. "Synthesis of new 1,2 dithiol 3-thione fluoroquinolone esters possessing anticancer activity in-vitro". Iraqi Journal of Veterinary Sciences, 26, Suppl. IV, 2012, 115-121. doi: 10.33899/ijvs.2012.168748
(2012). 'Synthesis of new 1,2 dithiol 3-thione fluoroquinolone esters possessing anticancer activity in-vitro', Iraqi Journal of Veterinary Sciences, 26(Suppl. IV), pp. 115-121. doi: 10.33899/ijvs.2012.168748
Synthesis of new 1,2 dithiol 3-thione fluoroquinolone esters possessing anticancer activity in-vitro. Iraqi Journal of Veterinary Sciences, 2012; 26(Suppl. IV): 115-121. doi: 10.33899/ijvs.2012.168748
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