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Synthesis of new 1,2 dithiol 3-thione fluoroquinolone esters possessing anticancer activity in-vitro

    Authors

    • B.B. Saeed 1
    • M.A. Al-Iraqi 1
    • F.T. Abachi 2

    1 Department of Chemistry, College of Science, University of Mosul, Mosul, Iraq

    2 Department of Pharmaceutical Science, College of Pharmacy, University of Mosul, Mosul, Iraq,

,

Document Type : Research Paper

10.33899/ijvs.2012.168748
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Abstract

Three 1,2 dithiole 3-thion fluoroquinolone esters (2-4) were prepared via condensation of (p-hydroxyl phenyl) -1,2dithiole- 3-thione with fluoroquinolones (Ciprofloxacin, Gatefloxacin and Moxifloxacin). The biological activity of these compounds was assayed against 60 types of cancer cells in vitro. The compound 2 (NSC=760553) showed anticancer activity against renal cell, while the comound 4 (NSC=760555) show activity against three types of cancer cell. The expected mechanism of their activity is that 1,2dithiole 3-thione derivatives may give H2S as new gas transmitter which play an important role in the biological systems.

Keywords

  • Fluoroquinolone
  • Anticancer
  • Ciprofloxacin
  • Gatefloxacin
  • Moxifloxacin

Main Subjects

  • Veterinary Pharmacology and Toxicology
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Iraqi Journal of Veterinary Sciences
Volume 26, Suppl. IV - Issue Serial Number 5
September 2012
Page 115-121
Files
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  • PDF 321.06 K
History
  • Received: 01 February 2012
  • Revised: 01 March 2012
  • Accepted: 01 April 2012
  • Published: 01 September 2012
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  • Article View: 338
  • PDF Download: 207

APA

Saeed, B., Al-Iraqi, M., & Abachi, F. (2012). Synthesis of new 1,2 dithiol 3-thione fluoroquinolone esters possessing anticancer activity in-vitro. Iraqi Journal of Veterinary Sciences, 26(Suppl. IV), 115-121. doi: 10.33899/ijvs.2012.168748

MLA

B.B. Saeed; M.A. Al-Iraqi; F.T. Abachi. "Synthesis of new 1,2 dithiol 3-thione fluoroquinolone esters possessing anticancer activity in-vitro". Iraqi Journal of Veterinary Sciences, 26, Suppl. IV, 2012, 115-121. doi: 10.33899/ijvs.2012.168748

HARVARD

Saeed, B., Al-Iraqi, M., Abachi, F. (2012). 'Synthesis of new 1,2 dithiol 3-thione fluoroquinolone esters possessing anticancer activity in-vitro', Iraqi Journal of Veterinary Sciences, 26(Suppl. IV), pp. 115-121. doi: 10.33899/ijvs.2012.168748

VANCOUVER

Saeed, B., Al-Iraqi, M., Abachi, F. Synthesis of new 1,2 dithiol 3-thione fluoroquinolone esters possessing anticancer activity in-vitro. Iraqi Journal of Veterinary Sciences, 2012; 26(Suppl. IV): 115-121. doi: 10.33899/ijvs.2012.168748

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