College of Veterinary Medicine / University of Mosul
  • Register
  • Login
  • العربیة

Iraqi Journal of Veterinary Sciences

Notice

As part of Open Journals’ initiatives, we create website for scholarly open access journals. If you are responsible for this journal and would like to know more about how to use the editorial system, please visit our website at https://ejournalplus.com or
send us an email to info@ejournalplus.com

We will contact you soon

  1. Home
  2. Volume 26, Issue Suppl. III
  3. Authors

Current Issue

By Issue

By Subject

Keyword Index

Author Index

Indexing Databases XML

About Journal

Aims and Scope

Editorial Board

Editorial Staff

Facts and Figures

Publication Ethics

Indexing and Abstracting

Related Links

FAQ

Peer Review Process

News

Pathological changes in liver and intestine of rats experimentally intoxicated by the alcoholic extract of Citrullus colocynthis fruits

    A. M. Rahawi S. O. Youkana

Iraqi Journal of Veterinary Sciences, 2012, Volume 26, Issue Suppl. III, Pages 233-239
10.33899/ijvs.2012.168706

  • Show Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract

This study reports the clinical signs and gross and histopathological changes that occurred in liver and intestine of male rats given alcoholic extract of citrullus colocynthis fruits. The LD50 was determined by the up-and-down method. The second part aimed to determine the dose that does not cause death of rats but revealed the toxic effect of alcoholic extract of citrullus colocynthis fruits and reveal the toxic signs and pathological changes at 1-6th week of treatment at 300 mg/kg, orally. Result showed that the LD50 of citrullus colocynthis fruit extract was 373.7 mg/kg of body weight, while the dose of 300 mg/kg of body weight was the best dose that lead to appearance of clinical signs of toxicity during 1-2 hours after administration. The main clinical signs were depression, inappetance, accumulation in groups and hemorrhagic diarrhea; these signs increased in the second week and decreased in severity at the end of the experiment. The gross pathological lesions were congestion of the internal organs especially liver and mucus material was found in the intestinal lumen. The histopathological changes included fatty change with congestion of sinosoids and infiltration of inflammatory cells in portal areas. Mucinous degeneration with sloughing of epithelial cells and hyperplasia were seen in the intestine.
Keywords:
Main Subjects:
  • Veterinary Pathology
  • PDF (320 K)
  • XML
(2012). Pathological changes in liver and intestine of rats experimentally intoxicated by the alcoholic extract of Citrullus colocynthis fruits. Iraqi Journal of Veterinary Sciences, 26(Suppl. III), 233-239. doi: 10.33899/ijvs.2012.168706
A. M. Rahawi; S. O. Youkana. "Pathological changes in liver and intestine of rats experimentally intoxicated by the alcoholic extract of Citrullus colocynthis fruits". Iraqi Journal of Veterinary Sciences, 26, Suppl. III, 2012, 233-239. doi: 10.33899/ijvs.2012.168706
(2012). 'Pathological changes in liver and intestine of rats experimentally intoxicated by the alcoholic extract of Citrullus colocynthis fruits', Iraqi Journal of Veterinary Sciences, 26(Suppl. III), pp. 233-239. doi: 10.33899/ijvs.2012.168706
Pathological changes in liver and intestine of rats experimentally intoxicated by the alcoholic extract of Citrullus colocynthis fruits. Iraqi Journal of Veterinary Sciences, 2012; 26(Suppl. III): 233-239. doi: 10.33899/ijvs.2012.168706
  • RIS
  • EndNote
  • BibTeX
  • APA
  • MLA
  • Harvard
  • Vancouver
  • Article View: 152
  • PDF Download: 134
  • LinkedIn
  • Twitter
  • Facebook
  • Google
  • Telegram
  • Home
  • Glossary
  • News
  • Aims and Scope
  • Privacy Policy
  • Sitemap

 

© 2023, College of Veterinary Medicine, University of Mosul

 
This journal is licensed under a Creative Commons Attribution 4.0 International (CC-BY 4.0)

Powered by eJournalPlus