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Effect of dermal administration of cypermethrin on some biochemical parameters in male rats

    Authors

    • A.A. Azeez
    • N. A. Al-Hussary

    Department of Physiology, Biochemistry & Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq

,

Document Type : Research Paper

10.33899/ijvs.2020.166876
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Abstract

Cypermethrin is synthetic pesticide that has been in use for more than a decade with low mammalian toxicity. This study was carried out to evaluate the effect of cypermethrin on some biochemical parameters in blood and both muscle and liver tissue. Adult male rats were used to determine the median lethal dose within 24 hours and been relied on them to take the 1/10 of the median lethal dose to expose the skin of rats daily for periods of 4 weeks. The results showed that cypermethrin caused a significant increase in levels of glucose, creatinine,urea, uric acid and malondialdelyde and activities of aspartate amino transferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase and gamma glutamyl transferase in the serum. There were also reduced the levels of total protein, albumin, globulin and glutathione in the serum. Glycogen levels in both liver and muscle decreased significantly. It is concluded from the present study that daily skin exposure to cypermethrin induced alterations in some biochemical parameters in blood and tissues of liver and muscle in rats.

Main Subjects

  • Veterinary Biochemistry
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Iraqi Journal of Veterinary Sciences
Volume 26, Suppl. II - Issue Serial Number 3
September 2012
Page 67-73
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  • PDF 273.07 K
History
  • Received: 02 October 2020
  • Accept: 02 October 2020
  • Publish: 02 October 2020
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  • Article View: 378
  • PDF Download: 270

APA

Azeez, A., & Al-Hussary, N. A. (2012). Effect of dermal administration of cypermethrin on some biochemical parameters in male rats. Iraqi Journal of Veterinary Sciences, 26(Suppl. II), 67-73. doi: 10.33899/ijvs.2020.166876

MLA

A.A. Azeez; N. A. Al-Hussary. "Effect of dermal administration of cypermethrin on some biochemical parameters in male rats". Iraqi Journal of Veterinary Sciences, 26, Suppl. II, 2012, 67-73. doi: 10.33899/ijvs.2020.166876

HARVARD

Azeez, A., Al-Hussary, N. A. (2012). 'Effect of dermal administration of cypermethrin on some biochemical parameters in male rats', Iraqi Journal of Veterinary Sciences, 26(Suppl. II), pp. 67-73. doi: 10.33899/ijvs.2020.166876

VANCOUVER

Azeez, A., Al-Hussary, N. A. Effect of dermal administration of cypermethrin on some biochemical parameters in male rats. Iraqi Journal of Veterinary Sciences, 2012; 26(Suppl. II): 67-73. doi: 10.33899/ijvs.2020.166876

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