The aim of this study was to evaluate the effects of platelets rich fibrin and bone marrow on distal radial fracture healing in local breed dogs. Twenty four adult animals (males and females), mean aged 2.6 ±0.15 years, and the mean body weight 24.58 ±1.07 kg were used. The experimental animals were randomly divided into three equal groups. First group (Control group), transverse fracture was induced in the distal portion of radial bone and immobilized by Plaster of Paris, the fracture line didn't treated with any material. Second group (platelets rich fibrin group), the fracture line was surrounded by the platelets rich fibrin. Third group (bone marrow group), the fracture line was surrounded by autologous bone marrow. The radiographic results confirmed that the fracture healing was faster and superior in third group compared with first and second groups. The hematological results showed an increasing in concentration rates of alkaline phosphatase enzyme and calcium at the weeks that follows surgical operation. Depending on the serial rates of alkaline phosphatase, the third group and the second group are the better fractured bone healing than the first group. In conclusion, the results revealed that, the using of bone marrow and platelets rich fibrin improved and enhanced the healing of distal radial fracture.