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Pathological study of subchronic oral toxicity induced by Di (2- ethyl hexyl) phthalate in Japanese quails

    Authors

    • Saevan Saad Al-Mahmood
    • Saeed Majed Al-Abady

    Department of Pathology and Poultry Diseases, College of Veterinary Medicine, University of Mosul, Mosul - Iraq

,

Document Type : Research Paper

10.33899/ijvs.2017.145567
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Abstract

In present study, we aimed to investigate the pathological changes induced by subchronic oral toxicity induced by sub lethal dose of Di (2-ethyl hexyl) phthalate (DEHP) in Japanese common quail. Forty male quails at one day old were divided randomly into two equal groups, the first group (treated group) was orally administrated by 10% of LD50 of DEHP (557.41 mg/kg of body weight) for 42 days, while second group (control group) left without treatment throughout experiment period. The results of current study showed that there is congestion of kidney, microscopically they showed presence of hyaline degeneration in renal tubules, glomerulosclerosis, wide spread of degenerative and necrotic lesions in renal tubules, hemorrhage, infiltration of inflammatory cell especially macrophages and lymphocytes in interstitial tissue of kidney. While grossing of liver showed hepatomegaly with hemorrhage, microscopically the sections showed wide distributing of vacuolar degeneration (fatty change) in different size and shape of vacuoles in cytoplasm of affected hepatocytes, infiltration of inflammatory cells mainly macrophages and lymphocytes. In conclusion, the oral administration of DEHP at dose 557.41 mg/kg of body weight for 42 days induced degenerative and necrotic irreversible changes in both kidney and liver of Japanese quail that affect their health and production.

Keywords

  • Pathology
  • Subchronic toxicity
  • DEHP
  • Quails
  • kidney
  • Liver

Main Subjects

  • Poultry Vaccine and Biosecurity
  • Veterinary Pathology
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Iraqi Journal of Veterinary Sciences
Volume 31, Issue 2
December 2017
Page 67-71
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History
  • Received: 01 December 2017
  • Revised: 20 December 2017
  • Accepted: 25 December 2017
  • Published: 28 December 2017
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APA

Al-Mahmood, S., & Al-Abady, S. (2017). Pathological study of subchronic oral toxicity induced by Di (2- ethyl hexyl) phthalate in Japanese quails. Iraqi Journal of Veterinary Sciences, 31(2), 67-71. doi: 10.33899/ijvs.2017.145567

MLA

Saevan Saad Al-Mahmood; Saeed Majed Al-Abady. "Pathological study of subchronic oral toxicity induced by Di (2- ethyl hexyl) phthalate in Japanese quails". Iraqi Journal of Veterinary Sciences, 31, 2, 2017, 67-71. doi: 10.33899/ijvs.2017.145567

HARVARD

Al-Mahmood, S., Al-Abady, S. (2017). 'Pathological study of subchronic oral toxicity induced by Di (2- ethyl hexyl) phthalate in Japanese quails', Iraqi Journal of Veterinary Sciences, 31(2), pp. 67-71. doi: 10.33899/ijvs.2017.145567

VANCOUVER

Al-Mahmood, S., Al-Abady, S. Pathological study of subchronic oral toxicity induced by Di (2- ethyl hexyl) phthalate in Japanese quails. Iraqi Journal of Veterinary Sciences, 2017; 31(2): 67-71. doi: 10.33899/ijvs.2017.145567

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