This study was carried out on 100 Kidney Samples collected from clinically healthy cattle slaughtered at Mosul abattoir to investigate the renal lesions and to isolate the bacterial causes of these lesions. The bacterial isolation included E. Coli 32%, Corynebacterium spp 27%, Proteus spp 16%, Staphylococus spp 12%, Streptococsus spp 7% while 6% of samples showing no bacterial isolation. The most common gross lesions were seen included multifocal white spots, swallen pale kidneys, congested enlarged kidneys, hyperemic hemorrhagic kidneys. The common observation in histopathological examination reveled to multifocal infiltration of inflammatory cells (Monocytes, Macrophages and Lymphocytes), degeneration and necrosis of epithelial cells lining renal tubules with infiltration of inflammatory cells in the interstitial tissues with atrophy of glomerular tufft. Additionally cysts were observed in kidney tissues.