The current study was conducted to compare between two methods of small intestinal anastomosis in dogs after obliquely resected and anastomosed by using simple interrupted and cross mattress sutures technique. The results revealed that the oblique technique of intestinal anastomosis was successful in all operative animals with few complications and without mortality rate postoperatively. The postmortem examination revealed that the cross mattress technique was associated with minimal adhesion as compare to simple interrupted technique which was associated with sever adhesion .The radiographic study revealed that no significant differences in mean degree of stenosis between two methods of this study. Also the radiographic pictures revealed that, the mean degree of stenosis which associated with cross mattress pattern was less than accompanied with simple interrupted pattern at thirty days after operation. The histopathological examination shown minute foci of tissue reaction with thick and mature fibrous tissue at the site of operation after 30 days in cross mattress anastomosis, whereas the anastomosis with the simple interrupted suture accompanied by sever inflammation and destruction of the serosal layer of intestine at 30 days after operation .We concluded that simple interrupted and cross mattress patterns can be used for anastomosis of oblique intestinal resection.