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Iraqi Journal of Veterinary Sciences

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Effect of treating lactating rats with lead acetate and its interaction with vitamin E or C on neurobehavior, development and some biochemical parameters in their pups

    H. M. Jassim A. A. Hassan

Iraqi Journal of Veterinary Sciences, 2010, Volume 24, Issue 1, Pages 45-52
10.33899/ijvs.2010.5584

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Abstract

The current study investigated the effect of administration of vitamin E (600mg/ kg diet) concomitantly with lead acetate (10mg/kg, orally) and vitamin C (100mg/kg, orally) concomitantly with lead acetate (10mg/kg, orally) to the female lactating rats on the neurobehavioral, landmarks development and some biochemical tests in their pups. Administration of lead acetate to the female lactating rats caused a significant increase in open field activity test including (the number of squares crossed and rearing test within 3 minutes), olfactory discrimination test, triglycerides and malondialdehyde brain tissue, with a significant decrease in glutathione brain tissue and high density lipoproteins in their pups. The present study demonstrated that treatment of female lactating rats with vitamin C and lead acetate produced a significant decrease in righting reflex test in their pups. Administration of vitamin E concomitantly with lead acetate to the female lactating rats caused a significant increase in glutathione level accompanied with a significant decrease in malondialdehyde and triglycerides levels in their pups. The present study showed that treatment of female lactating rats with vitamin E or C with lead acetate produced a significant decrease in rearing test, whereas a significant increase in high density lipoproteins in their pups. It is concluded that administration vitamin E or C to the female lactating rats reverse the adverse effects produced by lead acetate on neurobehavioral. Vitamin E had positive effect on the levels of glutathione, malondialdehyde brain tissue, triglyceride and high density lipoproteins in their lactating pups.
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(2010). Effect of treating lactating rats with lead acetate and its interaction with vitamin E or C on neurobehavior, development and some biochemical parameters in their pups. Iraqi Journal of Veterinary Sciences, 24(1), 45-52. doi: 10.33899/ijvs.2010.5584
H. M. Jassim; A. A. Hassan. "Effect of treating lactating rats with lead acetate and its interaction with vitamin E or C on neurobehavior, development and some biochemical parameters in their pups". Iraqi Journal of Veterinary Sciences, 24, 1, 2010, 45-52. doi: 10.33899/ijvs.2010.5584
(2010). 'Effect of treating lactating rats with lead acetate and its interaction with vitamin E or C on neurobehavior, development and some biochemical parameters in their pups', Iraqi Journal of Veterinary Sciences, 24(1), pp. 45-52. doi: 10.33899/ijvs.2010.5584
Effect of treating lactating rats with lead acetate and its interaction with vitamin E or C on neurobehavior, development and some biochemical parameters in their pups. Iraqi Journal of Veterinary Sciences, 2010; 24(1): 45-52. doi: 10.33899/ijvs.2010.5584
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