The current study aimed to identified the pathological changes of oral toxicity induced by Di (2-ethyl hexyl) phthalate (DEHP) in Japanese common quail. To a chief this aim a pilot study conducted to determine the median lethal dose (LD50) of DEHP. Forty male quails one day old were divided randomly into two equal groups, the first group was orally administrated by 10% of LD50 of DEHP daily for fourteen days, while second group was considered as control group and left without treatment all over the experimental time. The result of pilot study showed that the LD50 of DEHP in quails is 5574,1 mg/kg of body weight and the dose used in experiment to induced the acute oral toxicity was 557.4 mg/kg of quail's body weight. The result of gross pathological appearance of euthanized quails at fourteen days of experiment revealed presence of sever congestion in kidney lobules as well as congestion of liver with hemorrhagic ecchymotic patches while at other case the liver appear pale in color. The histopathology of kidney revealed presence of degenerative changes represented by cloudy swelling of the cell lining renal tubules lead to narrowing the lumen of affected tubules as well as interstitial edema with coagulative necrosis associated by infiltration of inflammatory cells as well as interstitial hemorrhage. The liver sections revealed presence of fatty change in hepatocytes in which the liver cell contained vacuoles of different size and shape also hepatocytes suffered from coagulative necrosis with infiltration of mononuclear inflammatory cells as macrophages with presence of hemorrhage. We conducted from current study that the oral administration of plasticizer DEHP in fourteen days at dose of 557.4 mg/kg of quail body weight induced degenerative and coagulative necrosis in both kidney and liver tissue in Japanese common quail.