TY - JOUR ID - 174960 TI - Curative and protective potentials of Moringa oleifera leaf decoction on the streptozotocin-induced diabetes mellitus in albino rats JO - Iraqi Journal of Veterinary Sciences JA - IJVS LA - en SN - 1607-3894 AU - Refat, Nahla A. AU - Abou El-Fattouh, Moustafa S. AU - Mohamed Metwally, Mohamed M. AU - Khamis, Tarek AU - Abdalla, Mohamed A. AD - Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt AD - Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt Y1 - 2023 PY - 2023 VL - 37 IS - 1 SP - 73 EP - 82 KW - Diabetes Mellitus KW - IHC KW - liver KW - kidney KW - Pancreas DO - 10.33899/ijvs.2022.133509.2242 N2 - The present study was designed to investigate the protective, and curative potentials of Moringa oleifera (MO) leaves powder against streptozotocin (STZ) induced type 1 diabetes mellitus (T1DM) in rats. Fifty adult Wistar male albino rats were randomized and divided into five equal groups: The normal control group, the Moringa group, The diabetic group, the therapeutic group, and the diabetic rats (3 days after STZ injection) were received-MO-for successive 8 weeks and the prophylactic group, the rats were received-MO-for 2 weeks before STZ induced diabetic rats and lasted for 8 weeks. The protective or treated oral administration of 1 ml freshly prepared aqueous leaf decoction of-MO-revealed a significant upregulation of the mRNA expression of PDX-1, Ngn3, VEGF, IGF-1, and GLUT-2. Additionally, it induced a significant downregulation of FBG level compared to that of the diabetic group, a significant reduction in MDA level and a significant elevation in the TAC level. Furthermore, the histopathological observations of pancreas, liver, and kidney tissues affirmed the improvement in treated and prophylactic groups compared to STZ-diabetic groups, and the improvement in the prophylactic group was more distinct than the treated group. MO-aqueous leaf extract can treat and protect against STZ-induced T1DM; via its antioxidant action (increase the TAC and decrease MDA). Thus, it has the potential for utilization as a prophylactic against diabetes. UR - https://www.vetmedmosul.com/article_174960.html L1 - https://www.vetmedmosul.com/article_174960_992d75417d695ae98b6444247506a627.pdf ER -