TY - JOUR ID - 173286 TI - In vivo study of Impact Transplantation Hematopoietic Progenitor Cells on Induced Cutaneous Wound Healing in Rabbits Model JO - Iraqi Journal of Veterinary Sciences JA - IJVS LA - en SN - 1607-3894 AU - Zedan, Zahraa K. AU - Hassan, Salah A. AD - Department of molecular and medical Biotechnology, College of Biotechnology, Al-Nahrain University, Baghdad, Iraq AD - Departments of Surgery and Obstetrics, College of Veterinary Medicine, Al- Qasim Green University, Babylon, Iraq Y1 - 2022 PY - 2022 VL - 36 IS - 3 SP - 579 EP - 589 KW - Cutaneous wounds,, KW - ,،,؛HSCs,, KW - ,،,؛rabbit,, KW - ,،,؛wounds healing DO - 10.33899/ijvs.2021.130949.1899 N2 - The goal of this study was to assess the effects of the Hematopoietic Progenitor Cells (HSCs) on full-thickness cutaneous wounds healing in rabbits. Twenty clinically healthy adult New Zealand White rabbits were used in this study; under aseptic technique and general anesthesia full-thickness excisional cutaneous wound; 20 mm x 20 mm were made on the back. The rabbits were randomly partitioned into two. In first group (control group), the wounds were treated with 3ml of saline solution. In second group (Hematopoietic Progenitor Cells- group); wounds were treated with 5x106 (Hematopoietic Progenitor Cells). The result of molecular evaluation along the interval of following-up recorded a significant differences (P<0.05) of the level Fibroblasts Growth Factor (FGF) and Vascular Endothelial Growth Factor (VEGF) recorded at 7, 14 and 35 day post-surgical operation in (Hematopoietic Progenitor Cells- group) compare than control group. These outcomes were parallel with the finding of the clinical and histopathological assessment showed that Hematopoietic Progenitor Cells- group reduces inflammation and promotes epithelialization during 3th weeks with increased vasculature than those in untreated wounds. This study confirms that local implantation of Hematopoietic Progenitor Cells leads to enhance and develop of cutaneous wound healing in rabbit model. UR - https://www.vetmedmosul.com/article_173286.html L1 - https://www.vetmedmosul.com/article_173286_867bdcc323adb5b945763c7f08225d4c.pdf ER -