TY - JOUR ID - 168005 TI - Pathological and biological effects of treatments with lambda-cyhalothrin in rabbits JO - Iraqi Journal of Veterinary Sciences JA - IJVS LA - en SN - 1607-3894 AU - BOUMEZRAG, Assia AU - HEMIDA, Houari AU - BOUMEZRAG, Fadhela Amina AU - SMAIL, Fadh AU - CISSE, Sekhou AD - Departement of Biomedecine, Veterinary Institute, University of Tiaret AD - Departement of Animal Health, Veterinary Institute, University of Tiaret AD - Faculty of Nature and Life Sciences, Ibn-Khaldoun University of Tiaret, 14000 Tiaret, Algeria AD - Angers University, France Y1 - 2021 PY - 2021 VL - 35 IS - 3 SP - 443 EP - 450 KW - Lambda-cyhalothrin KW - Rabbit KW - Hematology KW - biochemical parameters KW - Histopathology DO - 10.33899/ijvs.2020.126977.1425 N2 - Lambda-cyhalothrin (LCT) is a type II pyrethroid insecticide, which is widely used to control a large variety of agricultural pests throughout the world as well as in Algeria. The aim of this study was to investigate the effects of LCT exposure on body weight, hematological and blood biochemical parameters and to evaluate histopathological changes in some organs. Twelve (12) healthy local rabbits with a mean body weight of 1.8 kg were divided into three groups of four each: First group was kept as control (CTRL), second group (LCT 10) and third group (LCT 20) were given oral LCT at 10 and 20 mg/kg b.w, respectively three times a week for 25 days. The results showed no significant difference in mean body weight between groups. Blood analysis revealed no significant variation in hemogram between LCT-treated groups and control group. Serum biochemical analysis revealed a significant increase (P˂0.05) in total cholesterol content and glucose in LCT10 and LCT20, respectively. Total protein increased significantly (P˂0.0001) in LCT 20 group. While a very high increase (P˂0.0001) in the activity of asparatate aminotranferase (AST) was recorded in both treated groups, no change was observed in the activity of alanine aminotransferase (ALT). LCT treatment exhibited severe histopathological changes in liver, kidney, lung and brain. It is concluded from the study that LCT produced serious toxic pathological alterations and metabolic dysfunctions in rabbits. UR - https://www.vetmedmosul.com/article_168005.html L1 - https://www.vetmedmosul.com/article_168005_2461479b2d232195c945eb06dccc4011.pdf ER -