TY - JOUR ID - 166479 TI - Effect of levofloxacin on some body tissues in mice JO - Iraqi Journal of Veterinary Sciences JA - IJVS LA - en SN - 1607-3894 AU - Abdullah, Rand A. AU - Taee, Faten D. AU - Thanoon, Imad A. AD - Department of Anatomy, College of medicine, University of Mosul, Mosul, Iraq AD - Department of Anatomy, College of Medicine, University of Mosul, Mosul, Iraq AD - Department of pharmacology, College of Medicine, University of Mosul, Mosul, Iraq Y1 - 2021 PY - 2021 VL - 35 IS - 1 SP - 109 EP - 111 KW - Levofloxacin KW - liver KW - Heart KW - mice DO - 10.33899/ijvs.2020.126416.1316 N2 - Levofloxacin is a third generation of fluoroquinolones family. It is commonly used in the treatment of a several bacterial infections. However, misusing antibiotics impose damage to hepatocytes and myocytes. The present study was conducted to access the effect of levofloxacin on tissue histology in mice taking in consideration dose and duration of exposure. 24 matured male Albino mice were divided into 3 groups, Group G1: was considered as a control group. They received normal saline intraperitoneally / day. Group G2: They received 10.7 mg/kg/day of levofloxacin intraperitoneally for 10 days. Group G3: They received 10.7 mg/kg/day of levofloxacin intraperitoneally for 3 weeks. Microscopic examination of liver sections of group G2 revealed severe congestion of blood vessels in the portal area and central veins with inflammatory cells infiltration. While in group G3, Apoptosis, Degeneration and necrosis of hepatocytes with giant cell transformation were noticed. In addition to kupffer’s cell activation. Heart sections showed moderate congestion of blood vessels with edema in between the myocytes and inflammatory cells infiltration. Group G3 Necrosis with pyknosis of cardiac muscle nuclei was noticed. We concluded that levofloxacin induces toxic effects on liver and heart according to the dose of administration and duration of treatment. UR - https://www.vetmedmosul.com/article_166479.html L1 - https://www.vetmedmosul.com/article_166479_d7843a063a6bc534205dedc78052cffa.pdf ER -