Iraqi Journal of Veterinary Sciences

The aim of this study was conducted to evaluate the effect of Gundelia tournefortii on some biochemical parameters in hyperglycemic and hyperlipidemic mice. Male albino mice were induced hyperglycemic and hyperlipidemic by daily injection of dexamethasone 1 mg/kg of body weight intramuscularly (i.m.), the mice randomly divided into five groups (6-8 mice in each group). The group 1: served as negative control group; the group 2: injected with dexamethasone at dose 1 mg /kg.b.w.i.m and served as positive control group; the groups 3, 4, 5: treated with extract of G. tournefortii at doses: 75, 150, 300 mg/kg.b.w. orally respectively companied with injection of dexamethasone 1 mg/kg.b.w.i.m. All treatment were once daily for 22 days. Dexamethasone treatment lead to significant increase in levels of glucose, cholesterol, and triglyceride, and significant decrease of body weight, without any effect on level of total protein. G. tournefortii extract treatment at doses: 75 mg/kg.b.w. resulted significant decrease levels of glucose, and body weight. Beneficial effect were seen when mice treated with G. tournefortii at dose of 300 mg/kg.b.w. that lead to significant decrease in levels of glucose, triglyceride, and cholesterol. These results indicate the usefulness of G. tournefortii extract as hypoglycemia and hypolipidemia in dexamethasone treated mice.

Two years old Awassi ewe was brought by the owner to the clinic of the College of Veterinary Medicine, University of Mosul and he claimed that his animal had dystocia 12 hours ago. Fetal fluid was escaped since 3 hours ago. On clinical examination, the ewe was at term, as denoted by mammary changes and relaxed edematous vulva. The ewe was in a standing position and restlessness due to abdominal discomfort, without any abdominal contractions. Vaginal examination indicated that the cervix was dilated about 1 finger and the fetal membranes ruptured. No any medications were previously given to the ewe in the near past.

The present study was conducted to evaluate the effect of soybean seeds administration alone or combined with either insulin or glibenclamide on serum lipid profiles in diabetic rats. Male Wister rats were induced diabetes by a single subcutaneous injection of alloxan 100 mg/kg.b.w.The rats randomly divided into six groups (eight rats in each group): The first group served as a control, the second group was administered soybean seed 400 mg/kg.b.w orally as suspension, the third group injected insulin 10 I.U/kg.b.w, subcutaneously, the fifth group administered glibenclamide 5 mg/kg.b.w. orally. Accompaniment of soybean seeds with either of insulin or glibenclamide given the fourth and sixth groups, using the same routes and doses in the individual groups. All treatments were once daily for two weeks. Soybean seeds treatment alone resulted in an improvement of body weight and decrease of triglyceride and total lipids levels. While treatment with insulin or glibenclamide as alone or combination with soybean seeds showed a significant reduction in the levels of total cholesterol, triglyceride, low density lipoprotein, and total lipids, beside a significant increase in both body weight and high density lipoprotein. Beneficial effects were seen when soybean seeds combined with either of insulin or glibenclamide treatment. These results indicate the usefulness of soybean seeds in the management of diabetes through the hypolipidemic effects of soybean seeds in diabetic rats.