Keywords : Levothyroxine

Does Withania somnifera mitigate the structural alterations of the rat brain associated with propylthiouracil?

Luma I. Khalel; Osamah M. Al-Iraqi

Iraqi Journal of Veterinary Sciences, 2022, Volume 36, Issue Supplement I, Pages 187-194
DOI: 10.33899/ijvs.2022.135837.2534

The repercussion of propylthiouracil (PTU) use postnatally on brain histology have not yet been intensely scrutinized. To examine whether Withania somnifera mitigate the structural effects of propylthiouracil on rat brain, rats were distributed into group A enrolled ten pups that were received -orally- distilled water (D.W) daily from postnatal day (PND) 3 to PND 43. Group B: enrolled pups (n=8) subjected to oral doses of PTU (1 mg/kg/day) from PND 3 to PND 25. Then they were gavaged with D.W till PND 43. Group C: included pups (n=8) that were subjected orally to PTU (1mg/kg/day) PND 3 to PND 25 with receiving levothyroxine (four microgram /100g/day) from PND 25 to PND 43. Group D included pups (n=8) that were treated with oral PTU 1 mg/kg/day PND 3 to PND 25 with receiving Withania somnifera extract (200 mg/kg/day) from PND 25 to PND 43. Cerebellar sections of rats of group B exhibited disorganization of the cerebellar cortex with a falling off in the Purkinje cells' count and the appearance of degenerated cells. Hippocampal sections (of rats of group B) proclaimed a falling off in the breadth of the pyramidal zone of cornu Amonis. Sections of the cerebral cortex of rats in group B exhibited the presence of large degenerated neurons. Sections of rats' brains belonging to groups C and D showed improved cerebellar and cerebral cortex and hippocampal and cerebral cortical segments. Levothyroxine and Withania somnifera mitigates the structural changes in the peripubertal rat brain induced by postnatal PTU administration.

Effect of aqueous rosemary extract on some sexual hormones in male rats with high thyroxine level

Fouad Z. Hamza; Nabeel M. Al-Sharafi; Sumayah F. Kasim

Iraqi Journal of Veterinary Sciences, 2021, Volume 35, Issue 2, Pages 369-373
DOI: 10.33899/ijvs.2020.126872.1404

The main purpose of this research is to evaluate the high level of thyroxine affects on each of the luteinizing hormone (LH), testosterone, follicle-stimulating hormone (FSH) of rats and to estimate the potential effect of the administration of aqueous rosemary extract and propylthiouracil against testicular toxicity induced by levothyroxine in male rats. Negative control group rats were treated with distilled water. Three groups of male rats were treated subcutaneously with 0.5 mg/kg levothyroxine for 12 days: Since day 13th to the 24th day of the experiment first group was regarded as a positive control group that received distilled water, the second group was given propylthiouracil at a dose level of 10 mg/kg b.wt, and the third was given aqueous extracts of rosemary 10 mg/kg b.wt. The results revealed that treatment with aqueous extract of rosemary lead to a significant decrease in the levels of serum testosterone while a highly significant decrease in testosterone, FSH, and LH levels in serum revealed after treatment with propylthiouracil. Thus, it can be concluded that the effect of propylthiouracil and rosemary aqueous extract resulted in dialectical hormonal results in which the favor was to propylthiouracil.