Keywords : Ciprofloxacin

Effect of diclofenac on the pharmacokinetics of ciprofloxacin in quail

Yamama Z. Alabdaly

Iraqi Journal of Veterinary Sciences, 2021, Volume 35, Issue 4, Pages 777-781
DOI: 10.33899/ijvs.2021.128440.1576

This study investigated the Pharmacokinetics of ciprofloxacin alone or with diclofenac sodium in adult Japanese quails. The quails divided into two groups, the first group was dosed intraperitoneally with 50 mg/kg of ciprofloxacin, the second group was injected by 50 mg/kg of ciprofloxacin intraperitoneally then directly injected intraperitoneally by diclofenac sodium at a dosage of 5 mg/kg. Plasma concentrations of ciprofloxacin were determined by the spectrophotometer at wavelength 290 nm. Co-admiration of ciprofloxacin with diclofenac lead to appearing ciprofloxacin in plasma at 12.02, 6.4, 5.3, 3.30, 1.36, 0.60 μg/ml in the periods of 0.25, 0.50, 1, 2, 4 and 8 hours post-injection. A significantly increased in the concentration of ciprofloxacin at times of 0.25, 0.50, 1, and 2 hours post-injection and appeared at a concentration of 6.96, 3.09, 2.2, and 0.72 μg/ml. The pharmacokinetics of ciprofloxacin when given with diclofenac sodium was represented by 91% decrease in elimination constant rate, 53% decrease in elimination half-life t1/2, 64% decrease in volume of distribution to steady-state, 22% decrease in clearance, 28% increase area under curve, 41% decrease in area under moment curve, 53% decrease in mean residence time and 37% increase in maximum plasma concentration. Our study concludes that co-administration of ciprofloxacin with diclofenac sodium lead to alteration in some pharmacokinetic data of ciprofloxacin like effect on the plasma concentration and volume of distribution and clearance. This effect must be considered when therapy by ciprofloxacin with diclofenac, the co-administration of diclofenac with ciprofloxacin decrease the elimination of ciprofloxacin 

Ameliorative role of Arabic gum against nephrotoxicity induced by ciprofloxacin in rats

Abdullah Th. Abdullah; Measer Abdullah Ahmed

Iraqi Journal of Veterinary Sciences, 2021, Volume 35, Issue 4, Pages 789-798
DOI: 10.33899/ijvs.2020.127441.1503

Medicinal plants have gained wide popularity at present time due the side effects of chemical drugs on the body in general and on the kidneys in particular. This study aimed to explore the protective effect of Arabic gum (AG) against nephrotoxicity of ciprofloxacin. Twenty-four rats divided into four groups administrated for 14 days as following: control group administrated orally with distilled water 1 ml/kg, ciprofloxacin group 750 mg/kg, orally. Third group administrated with AG solution 15% and fourth group administrated with ciprofloxacin 750 mg/kg combined with AG 15% respectively. Results demonstrated the effect of Ciprofloxacin in significant increased levels of nephrotoxicity biomarkers such as blood urea nitrogen, creatinine, uric acid, MDA, and a significant decreased urine flow rate, creatinine clearance and degeneration in renal tissue via attenuate antioxidant system tissue. The combined administration of AG with Ciprofloxacin showed the ameliorative role of AG on nephrotoxicity biomarkers, nephron function, antioxidant availability and protected renal tissue from damage. We concluded that AG in concentration 15% has a protective role against renal toxicity exposed by ciprofloxacin in rats.

Histopathological changes in diseased and treated catfish (Clarias gariepinus) by ciprofloxacin and clove oil

S.S. Abd El-Salam; M.F. Ghaly; D.M. Baraka; S.H. Mahmoud; A.A. El-Makhzangy

Iraqi Journal of Veterinary Sciences, 2018, Volume 32, Issue 1, Pages 13-19
DOI: 10.33899/ijvs.2018.153788

Bacteria pathogens may cause a serious loss in aquaculture and also health hazards to humans. On the basis of biochemical characteristics and API-20E system, all isolates of pathogens from diseased fish were identified as Aeromonas spp, the most predominant bacterial species were A. sobria 46.7%, A. caviae 19.03%, A. jandaei 8.6 % and A. veronii 8.6 %. One hundred and twenty Nile catfish Clarias gariepinus were divided into four equal groups (1,2,3 and 4) were challenged with Aeromonas sobria which predominant isolates, Gp. (1) was challenged only, while Gps. (2, 3 and 4) were treated after challenged with ciprofloxacin, clove extract and ciprofloxacin and clove extract in combination, respectively. The antibacterial activity of antibiotic and clove extract in their therapeutic doses decrease the mortality rate as (20, 16 and 13%) respectively compared with non-medicated Gp. (1) which recorded mortality 83%. Internal signs of infection with Aeromonas sobria in African catfish (Clarias gariepinus) include congestion of the hepatic blood vessels, areas of coagulative necrosis in the liver and hydropic degeneration of renal tubules according to the histopathological examination. In-vivo the combination of ciprofloxacin and clove extract was the choice as alternative bacterial therapeutic agent in infected Clarias gariepinus with Aeromonas sobria. Moreover histopathological changes have been widely used as biomarkers in the evaluation of the health of fish exposed to contaminants.

Synthesis of new 1,2 dithiol 3-thione fluoroquinolone esters possessing anticancer activity in-vitro

B.B. Saeed; M.A. Al-Iraqi; F.T. Abachi

Iraqi Journal of Veterinary Sciences, 2012, Volume 26, Issue Suppl. IV, Pages 115-121
DOI: 10.33899/ijvs.2012.168748

Three 1,2 dithiole 3-thion fluoroquinolone esters (2-4) were prepared via condensation of (p-hydroxyl phenyl) -1,2dithiole- 3-thione with fluoroquinolones (Ciprofloxacin, Gatefloxacin and Moxifloxacin). The biological activity of these compounds was assayed against 60 types of cancer cells in vitro. The compound 2 (NSC=760553) showed anticancer activity against renal cell, while the comound 4 (NSC=760555) show activity against three types of cancer cell. The expected mechanism of their activity is that 1,2dithiole 3-thione derivatives may give H2S as new gas transmitter which play an important role in the biological systems.